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ea0035p8 | Adrenal cortex | ECE2014

Analysis of BclI, N363S and ER22/23EK polymorphism of the glucocorticoid receptor gene in a large series of patients with adrenal incidentaloma

Reimondo Giuseppe , Coletta Marcella , Giachino Daniela , Chiodini Iacopo , Kastelan Darko , Morelli Valentina , Cannavo Salvatore , Cuccurullo Alessandra , Beck-Peccoz Paolo , De Marchi Mario , Terzolo Massimo

Introduction: Some variants of the glucocorticoid receptor (GR) gene have been found to alter glucocorticoid sensitivity and have been associated with worsen metabolic profiles.Objective: The aims of the present study were: i) to examine whether the prevalence of N363S, ER22/23EK and BclI variants was different in patients with adrenal incidentaloma (AI) and/or subclinical Cushings syndrome (SCS) than control subjects and ii) whether the presence o...

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Analysis of BclI, N363S and ER22/23EK polymorphism of the glucocorticoid receptor gene in a large series of patients with adrenal incidentaloma

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